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What Happens If ADHD is Left Untreated in Adults? Untreated ADHD can lead to a range of issues for adults. can affect relationships, work and mental health. Adults suffering from untreated ADHD typically have low self-esteem and an unfavorable view of the world. This can cause them to feel as if they're failing in their work and at home. Lack of Focus It is normal to experience difficulties focusing from time to moment particularly after a hectic day at work or school. If

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Drug abuse is a foremost public health problem. Cocaine is a widely abused drug worldwide that produces various reward-related behaviors. The mechanisms that underlie cocaine-induced disorders are unresolved, and effective treatments are lacking. Here, we found that an autophagy-related protein Becn2 is a previously unidentified regulator of cocaine reward behaviors. Becn2 deletion protects mice from cocaine-stimulated locomotion and reward behaviors, as well as cocaine-induced dopamine accumulation and signaling, by increasing pres