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Motor function was also impaired in rats with HE (P .05). Human brains of patients with cirrhosis with HE also exhibited up-regulation of proinflammatory genes (NFKB1, IbA1, TNF-α, and IL1β) (n= 6). AAV8-VEGF-C injection significantly increased meningeal lymphangiogenesis (P= .035) and tracer dye uptake in the anterior and middle regions of the cortex (P= .006 and .003, respectively), their corresponding meninges (P= .086 and .006, respectively), and the draining lymph nodes (P= .02). Furthermore, AAV8-VEGF-C decreased microglia