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Undoubtedly, the main step towards optimizing patient outcomes is the development of cancer immunotherapy, by means of immune checkpoint inhibition (ICI). Immunotherapy has established its cardinal part in the management of both early and late-stage melanoma. Through leveraging outcomes in melanoma, immunotherapy has also extended its benefit to many other kinds of epidermis cancers. In this analysis, we endeavor to review current part of immunotherapy in melanoma and non-melanoma ep