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Furthermore, network-based bioinformatics helped us identify E3 RING ligase candidates which potentially exhibit similar structural modules as Ark2C, along with predicted substrates targeted by the Ub-binding RING Ark2C. Our findings could trigger a further exploration of related unrevealed functions of various other E3 RING ligases.We present a simple, low-cost, and environmental-friendly method for the fabrication of hybrid magnetorheological composites (hMCs) based on cotton fibers soaked with a mixture of silicone oil (SO), carbonyl ir