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Most participants were female (73%, 309/422); 66% (101/154) and 69% (184/268) of the general laboratory animal science respondents and the CRO respondents, respectively, reported experiencing feelings of CF. Survey participants indicated that the most influential work-related factors associated with feelings of CF were understaffing, close relationships with experimental animals, a lack of resources for coping with CF, poor relationships with superiors, and lack of training in managing CF. Respondents indicated that the most influential