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Enzyme replacement therapy, in which a functional copy of an enzyme is injected either systemically or directly into the brain of affected individuals, has proven to be an effective strategy for treating certain lysosomal storage diseases. The inefficient uptake of recombinant enzymes via the mannose-6-phosphate receptor, however, prohibits the broad utility of replacement therapy. Here, to improve the efficiency and efficacy of lysosomal enzyme uptake, we exploited the strategy used by diphtheria toxin to enter into the endolysosomal

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A Wood and White Cot Bed This crib is suitable for babies for babies from birth and has been designed to grow with your baby. It is made of European woods harvested sustainably. It features a curved design that can be easily incorporated into most spaces and can be converted to a toddler