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We explore trends in linkage to HIV care following diagnosis and investigate the impact of diagnosis setting on linkage in the era of expanded testing. All adults (aged≥15years) diagnosed with HIV between 2005 and 2014 in England, Wales and Northern Ireland (EWNI) were followed up until the end of 2017. People who died within 1month of diagnosis were excluded (n=1009). Trends in linkage to outpatient care (time to first CD4 count) were examined by sub-population and diagnosis setting. Logistic regression identified predictors of de

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74 °C. Using 100, 300, and 500 g L-1 of d-fructose as substrate, 25.6, 74.4, and 115 g L-1 of d-mannose were produced respectively, corresponding to a conversion rate of 25.6 %, 24.8 %, and 23.0 % under optimal conditions. Taken together, our results provide evidence for a promising candidate d-LIase for producing d-mannose directly from d-fructose.A novel prolyl endopeptidase from Stenotrophomonas maltophilia, SmPEP, was discovered and characterized. The specific activity of the recombinant SmPEP expressed by Escherichia coli BL21 (DE