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Background context Pre-existing comorbid psychiatric mood disorders are a known risk factor for impaired health-related quality of life and poor long-term outcomes after spine surgery. Purpose The purpose of this study was to investigate the effect of pre-existing mood disorders on (1) pre- and post-operative patient-reported outcomes, (2) complications, and (3) pre- and post-operative opioid consumption in patients undergoing elective cervical or lumbar spine surgery. Study design/setting Retrospective review at a single academic institut