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To work, it requires a joint between the upper and lower jaws, therefore jaw combined flaws tend to be very troublesome and hard to study. To spell it out the consequences of jaw-joint dysfunction, we designed two separate null alleles of a single jaw-joint marker gene, nkx3.2, in zebrafish. These mutations caused zebrafish to be functionally jawless via fusion of the top and reduced jaw cartilages (ankylosis). Despite lacking jaw joints, nkx3.2 mutants

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