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The development of effective drugs and vaccines against Vibrio parahaemolyticus is the current study priority. Hence, we aimed to find out effective medication and vaccine goals using a thorough genome-based analysis. A complete of 4822 proteins had been screened from V. parahaemolyticus proteome. Among 16 novel cytoplasmic proteins, 'VIBPA kind II release system necessary protein L' and 'VIBPA Putative fimbrial protein Z' had been put through molecular docking with 350 human metabolites, which