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Few research reports have investigated the relationship between serum total carbon dioxide (CO2) focus and bicarbonate ion (HCO3-) concentration in patients undergoing hemodialysis. We determined the agreement and discrepancy between serum total CO2 and HCO3- concentrations in addition to diagnostic accuracy of serum complete CO2 for the prediction of low (HCO3- 24 mEq/L) and high (HCO3- ≥ 24 mEq/L) bicarbonate concentrations in hemodialysis patients. A hundred forty-nine arteriovenous blood examples