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utation. Besides, we found that the blood haemoglobin level was higher in the ET patient group with JAK2 mutation. Additionally, the PCT level was higher in the CALR group when compared to the other patient groups. We developed and validated a set of composite scores that combine quantitative magnetic resonance (MR)-based measurements of hyaline cartilage damage, bone marrow lesions (BMLs), and effusion-synovitis into composite scores. We selected 300 participants (development cohort=100, validation cohort=20 from the Osteoarthritis In

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