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THBE formation is however associated with H3O+ generation favoring the appearance of side products (humins). We demonstrate that boric acid catalysis is not straightforward and that the use of THBE under moderate acidity should be further investigated to limit humins formation and promote furanic derivatives synthesis.Theranostics is a fast-growing field due to demands for new, efficient therapeutics which could be precisely delivered to the target site using multimodal imaging with enhancing auxiliary actions. In this review article we discuss th