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The inconsistency index (I2) and Chi-squared will be applied for heterogeneity detection between clinical trials. A value of P 0.05 will be considered statistically significant. The main outcomes of pooled evidence synthesis will be presented including the incidence of TB and adverse events. This study will provide the evidence of whether isoniazid is an effective and safe intervention for preventing TB for HIV-infected pregnant women. INPLASY202070011. INPLASY202070011.In the present study, we retrospectively analyzed the records o