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Collectively, our findings have implications for the design of efficacious targeted immunotherapeutic biologics, and ensembles thereof. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.The life diversity relies on a handful chemical elements (carbon, oxygen, hydrogen, nitrogen, sulphur and phosphorus) as part of essential building blocks, whereas other atoms are needed to a lesser extent and most of the remaining elements are excluded from biology. This circumstance limits the scope of biochemical reactions in extant metabolism - ye

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