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structures; GC germinal center(s); PDAC pancreatic ductal adenocarcinoma; RNA-seq RNA sequencing; BCRseq B cell receptor sequencing; HEV high endothelial venule; PNAd peripheral node addressin; TMB tumor mutational burden; TCGA the cancer genome atlas; PAAD pancreatic adenocarcinoma; FFPE formalin fixed paraffin embedded; TIME tumor immune microenvironment.Immunotherapy via interleukin-2 (IL-2) mediated activation of anti-tumor immune response is a promising approach for cancer treatment. The multi-potent cytokine, IL-2 has a central ro