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© 2020 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.Autologous stem mobile transplantation (ASCT) is possible and effective in selected older patients with Multiple Myeloma but specific criteria for assessing ASCT eligibility in elderly customers are lacking. We evaluated 131 patients aged 65-75 considered for ASCT at our center Charlson Comorbidity Index (CCI), Hematopoietic cellular transplantation comorbidity index (HCT-CI) and IMWG frailty score had been gotten at analysis, howev

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A decrease in plasma follicle stimulating hormone and luteinizing hormone concentrations was observed with injections of Spx1a or Spx1b in vivo. Additionally, application of Spx1a and Spx1b to pituitary slices decreased the firing rate of LH cells, suggesting that the peptides can act directly at the level of the pituitary. These data collectively suggest an inhibitory mechanism of action against the secretion of gonadotropins for a traditional and a novel spexin paralog in cichlid species. Copyright © 2020 Cohen, Hausken, Bonfil, Gut