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I group (P0.001). In passive avoidance task, the retention latency of I group was significantly shorter than S group (P0.001), and the retention latency of the 1RI, 1R and 4R, 4RI group were longer than I group (P0.001), there was no significant difference in S, 1RI, 1R, 4R and 4RI group (P0.05). In elevated plus maze test, the time and entrance numbers of open arms in I group were significantly less than S group (P0.05), but these indices were no significant difference in S, 1RI, 1R, 4RI and 4RI gr