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The use of extracorporeal membrane oxygenator (ECMO) has significantly increased in the past 20 years. There is a high incidence of acute kidney injury (AKI) in the group of patients on ECMO, with need for continuous renal replacement therapy (CRRT) in most of them. This article will review the basics of CRRT, its indications, the technical aspects of incorporating CRRT with ECMO circuit, data on clinical aspects, and outcomes. To review the relevant literature of acute kidney injury (AKI) and continuous renal replacement therapy (CRRT)