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To evaluate the clinical characteristics, genetic abnormalities, treatment efficacy and prognostic factors in patients with plasma cell leukemia(PCL). 30 patients diagnosed as PCL in our hospital from January 1993 to December 2019 were enrolled, and the clinical characteristics, laboratory findings, therapeutic regimes, and survival data of the patients were retrospectively analyzed. The median age of the 30 patients was 56.5 (28-8 years old, among them, 25 patients were primary plasma cell leukemia, and 5 patients were secondary plas