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In this analysis, we are going to deal with the neurobiological basics of sensory handling in ASD, with a specific focus of tactile susceptibility. In the 1st part, we will review more relevant sensory abnormalities detected in ASD, and then consider tactile handling deficits through the discussion of present clinical and experimental studies. Into the look for the neurobiological bases of ASD, several mouse designs have already been produced with knockout and humanized