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Somatic structural variant and copy number alterations were also investigated, but no potential driver event was identified. This study provides novel insight in the molecular mechanism of thyroid carcinoma development in dogs. German longhaired pointers carrying GNAS mutations in the tumor may be used as a disease model for the development and testing of novel therapies to kill the tumor with somatic mutations in the GNAS gene. This study provides novel insight in the molecular mechanism of thyroid carcinoma development in dogs. German