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Upon ATRA-TCP treatment, we observed significant induction of retinoic acid-target genes in responders but not nonresponders. We corroborated this in AML cell lines, showing that ATRA-TCP synergistically increased differentiation capacity and cell death by regulating the expression of key gene sets that segregate patients by their clinical response. These data indicate that LSD1 inhibition sensitizes AML cells to ATRA and may restore ATRA responsiveness in subsets of patients with MDS and AML. These data indicate that LSD1 inhibition sensi

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A Guide to Buying a Cheap Double Mattress A low-cost double mattress does not necessarily mean poor quality. Numerous reputable sleep brands offer mattresses for less than $1,000 for a queen-sized mattress. This is particularly true when you shop online, since you can save money if you don't use the middleman. Heavyweight sleepers may find cheaper mattresses break down more quickly, because the foam wi