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No changes in mRNA and protein levels of the renal uric acid transporter were observed. Ulodesine, allopurinol and febuxostat eliminated the inosine-induced elevation in SUA in tested monkeys. An acute HUA animal model with high reproducibility was induced; it can be applied to evaluate new anti-HUA drugs and explore the disease pathogenesis. An acute HUA animal model with high reproducibility was induced; it can be applied to evaluate new anti-HUA drugs in vivo and explore the disease pathogenesis.Severe acute respiratory syndrome-corona