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The prevalence of diabetic neuropathy is drastically increasing in the world. To halt the progression of diabetic neuropathy, there is an unmet need to have potential biomarkers for the diagnosis and new drug discovery. To study various biomarkers involved in the pathogenesis of diabetic neuropathy. The literature was searched with the help of various scientific databases and resources like PubMed, ProQuest, Scopus, and Google scholar from the year 1976 to 2020. Biomarkers of diabetic neuropathy are categorised as inflammatory biomarker