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( ) wild-type lower-grade gliomas (histologic grades II and III) with ( ) amplification or ( ) promoter mutation are reported to behave similar to glioblastoma. We aimed to evaluate whether MR imaging features could identify a subset of wild-type lower-grade gliomas that carry molecular features of glioblastoma. In this multi-institutional retrospective study, pathologically confirmed wild-type lower-grade gliomas from 2 tertiary institutions and The Cancer Genome Atlas constituted the training set (institution 1 and The Cancer Genome A
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