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Furthermore, the percentages of γδ T cells and the CD27-CD28+ γδ T-cell subset were both negatively correlated with that of Tregs. Therefore, the results of the present study indicate that CD27 and CD28 may be the key signals for activation of different γδ T-cell subsets and may contribute to the immune regulatory function of γδ T cells in the peripheral blood of patients with AR.Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease caused by the novel coronavirus SARS-CoV-2. It first became prevalent in Wuhan,