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The SCA5 associations were also largely bilaterally symmetrical. Both SCA1 and SCA5 demonstrated secondary associations with the right caudate, whereas the SCA6 group had no such associations. Conclusions These results demonstrate that although primary aspects of a brain network may remain functional, pathophysiological processes associated with different SCA genotypes may express themselves in alterations of broader, secondary brain networks. These secondary networks may reflect generic functional associations with the primary pr

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