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ADHD Treatment For Adults Stimulants like methylphenidate, amphetamine, and other brain chemicals can help increase levels. Nonstimulants like atomoxetine or antidepressants perform slower than stimulants but they could be as effective. Complicating conditions often affect the effectiveness of ADHD medication. Physicians should treat the most severe symptom of any comorbid disorder first, and then monitor whether the ADHD symptoms improve. Medication Medication is the most common form of treatm