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We showed that the morphology of ESC-derived aggregates and Zscan4 expression are purely intertwined. Our data claim that ESC Zscan4 metastate is promoted in the event that adhesive surface problems guide mobile self-aggregation into 3D dome-like structure, by which both cell-material communications and cell-cell contact are supporting for Zscan4 appearance. Copyright © 2020 Natale, Angrisano, Pistelli, Falco, Calabrò, Netti and Ventre.MicroRNAs (miRNAs) tend to be a kind of n
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