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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression People who suffer from untreated ADHD frequently suffer from chronic underachievement, which can lead to feelings of despair and depression. This is particularly true when they fail their professional and personal goals. Diagnoses aren't always easy to determine when there are symptoms that overlap between ADHD and depression. However, identifying the signs is the first step to finding treatment. 1. Feelings of Unworthiness M