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This commentary does not concern itself with the need for, or the value of glyphosate as an agrochemical rather it examines the scientific basis for the various conclusions reached at different times by a number of regulatory authorities and by the International Agency on Research on Cancer (IARC). Why do they differ? An appropriate regulatory stance depends critically on the application of good science and consistency in the application of established criteria. Constant reappraisal of the methodology used is essential. This article is