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Of 8739 hits, 48 citations had been included in this analysis. These scientific studies ranged from animal researches to randomized placebo-controlled medical trials. Within these scientific studies, local anti-TNF-α treatment ended up being achieved with antibodies, antisense oligonucleotides (ASO), little interfering RNA (siRNA), microRNA (miRNA) and genetically modified organisms. This narrative review summarizes and analyzes these techniques in view for the medical relevan