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Results After controlling for age, sex, and having history of diabetes mellitus, no relation was found between having depression symptoms and more frequency of vessel involvement (OR = 1.35, 95% CI 0.92 to 1.98, P =0.13 or higher severity of CAD (OR = 1.47, 95% CI 0.95 to 2.28, P = 0.087). The results were similar for the relation between severity of depression symptoms and CAD extent or CAD severity. Conclusion The results of this study showed that in patients undergoing angiography, depression symptoms were not related to CAD severity a