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Background Palliative care seeks to support the physical, psycho-social and spiritual needs of patients and families who are facing life threatening diseases. Advantages of establishing a palliative care unit, or alternatively co-locating patients, include promoting optimal physical and psychological symptom management; increased family satisfaction; and facilitating resource allocation. Objective To design a stand-alone hospital unit to provide end of life care during a pandemic. Setting Mount Sinai Hospital (MSH), a 1,144