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We also discuss the use of this knowledge to develop immune-based therapeutic approaches, including immunotherapy that targets α-synuclein and the targeting of immune mediators such as inflammasomes. We also consider future research and clinical trials necessary to maximize the potential of targeting the immune system.A basic question in cognitive neuroscience is how sensory stimuli are processed within and outside of conscious awareness. In the past decade, CFS has become the most popular tool for investigating unconscious