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This is a reason of concern; each of these analogs potentially presents with different toxicodynamic profiles, and there is a lack of docking, preclinical, and clinical observations. Strengthening multidisciplinary collaboration between clinicians and bioinformatics may prove useful in better assessing public health risks associated with opioids. Copyright © 2020 Arillotta, Schifano, Napoletano, Zangani, Gilgar, Guirguis, Corkery, Aguglia and Vento.Huntington disease (HD) is an autosomal dominant progressive neurodegenerative disorder a