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Treatment of Add in Adults Treatment of add in adults typically involves a combination of medication, life skills training, and psychotherapy. Most patients respond best to stimulant drugs like methylphenidate (Ritalin) and amphetamines, such as amphetamine lisdexamphetamine (Adderall) or extended-release mixed amphetamine salts (Adderall XR). Stimulants can increase blood pressure and heart rate. Nonstimulants, such as bupropion and atomoxetine impro