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ADHD Treatment Medication Treatment for ADHD for adults usually involves medication and psychosocial therapy. The drugs used to treat ADHD may include stimulants and nonstimulants. Stimulants, including methylphenidate and lisdexamfetamine, act on chemical messengers in the brain to boost mood concentration, concentration and impulse control. Atomoxetine and guanfacine, both of which are non-stimulant ADHD medications, can be prescribed to adults, teens or children who do not respond to s