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The longevity-related AMPK/SIRT1/PGC-1α signaling pathway and brain IGF1/PI3K/Akt survival pathway had been notably lower in D-galactose-induced aging group compared to non-aging control group and increased after workout education. The irritation pathway markers had been over-expressed in induced-aging hippocampus, workout dramatically inhibited the inflammatory signaling activity. Fas-dependent and mitochondrial-dependent apoptotic pathways had
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