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The pore formation dynamics revealed here may provide guidance on developing pore elimination approaches.The study was approved by the institutional review board (IR at the University Medical Center Campus Kiel, Kiel, Germany (reference number AZ D 559/18) and registered at the German Clinical Trials Register (reference number DRKS00022222). Unilateral pulmonary edema (UPE) is a complication after minimally invasive mitral valve surgery (MIMVS). We analyzed the impact of this complication on the short- and long-term outcome over a 10