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Different methods have been used to inject stem cells into the eye for research. We previously explored the intravitreal route. Here, we investigate the efficacy of intravenous and subretinal-transplanted human dental pulp stem cells (DPSCs) in rescuing the photoreceptors of a sodium iodate-induced retinal degeneration model. Three groups of Sprague Dawley rats were used intervention, vehicle group and negative control groups (n = 6 in each). Intravenous injection of 60mg/kg sodium iodate (day induced retinal degeneration. On day 4 po