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Multivariate analysis showed that the dynamics of PBL telomere shortening can be a consistent risk marker of knee OA incidence. Non-incidents showed a slower telomere loss than incidents, the difference being more significant in carriers of cluster JT than in HV. An increased telomere loss rate in PBL may reflect a systemic accelerated senescence phenotype which could be potentiated by the mitochondrial function, increasing the susceptibility of developing OA. An increased telomere loss rate in PBL may reflect a systemic ac

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