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BACKGROUND Plant lectins has shown promising biological activities in the central nervous system (CNS). OBJECTIVE This study evaluated the effect of DAL, a lectin isolated from the seeds of the Dioclea altissima species, has binding affinity to D-glucose or D-mannose residues, on mouse behavior. METHODS Mice (n=6/group) were treated (i.p.) with DAL (0.25, 0.5 or 1 mg/kg) or vehicle and submitted to several tests (open field/OFT, marble-burying/MBT, hole-board/HBT, elevated plus maze/PMT, tail suspension/TST, forced swimming/FST or rotar