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Xenograft bone substitutes are obtained from different species and prepared by various procedures including heat treatment, hydrazine, and chemical and hydrothermal methods. These grafts are utilized widely because of similar structure and properties to human bone, proper bone formation, and biocompatibility. The aim of this systematic review was to evaluate different xenografts from structural and chemical aspects. In vitro studies published in English language, which assessed xenografts' features, met the inclusion criteria. Electroni

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