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2020 Gland Surgery. All rights reserved.According to the Endocrine Society Clinical Practice Guidelines, the goal of treating overt Cushing's syndrome is to control cortisol levels or more importantly its actions at its receptor in order to eliminate the end organ effects and treat comorbidities associated with hypercortisolism. This chapter will review the surgical management of hypercortisolism. It will be subdivided into two main sections the management of (I) ACTH-dependent; and (II) ACTH-independent (adrenal) hypercortis