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The percentages and absolute variety of NK cells decreased, in addition to proportions of three significant NK cellular subsets defined by mobile maturation condition changed in SLE patients. The frequency of CD56brightCD16- NK (immature, Im NK) cells increased, while that of the CD57+CD56dimCD16- subset (mature, more differentiated, MD NK) decreased in patients with high-activity SLE, causing an important escalation in the Im NK-to-MD NK ratio when compared with that in clients with low-activity