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44 days (95% CI -3.79 to 0.91)) but did in cohort studies (MD -1.52 days (95% CI -2.71 to -0.34)). No statistically significant benefit of lighter sedation was identified in RCTs. In cohort studies, lighter sedation improved time to extubation, intensive care and hospital length of stay and ventilator-associated pneumonia. We found no significant effects for hospital mortality, delirium or adverse events. Evidence of benefit from lighter sedation is limited, with inconsistency between observational and randomised studies. Posi