https://www.selleckchem.com/pr....oducts/apr-246-prima
We demonstrate that mean lung density on CT as well as [ F]FDG and [ F]FMISO uptakes are upregulated in established lung fibrosis (1.4-, 2.6- and 3.2-fold increase respectively). At early stages, lung areas with [ F]FMISO uptake are still appearing normal on CT scans and correspond to areas which will deteriorate towards fibrotic lesions at later timepoints. Nintedanib and pirfenidone dramatically and rapidly decreased mean lung density on CT as well as [ F]FDG and [ F]FMISO lung uptakes (pirfenidone 1.2-, 2.9- and 2.6-fold d
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