https://www.selleckchem.com/products/hs-10296.html
Actin polymerization is a crucial process during capacitation. We have recently described the participation of FAK in actin polymerization in guinea pig spermatozoa. However, the mechanism by which FAK achieves these processes is unknown. Our data showed that ERK2 is activated during the first minutes of capacitation; its inhibition blocked actin polymerization and the acrosome reaction. Additionally, the present study found that FAK is involved in ERK2 activation since FAK was phosphorylated in Tyr925 and bound to Grb2 and that the in